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Istradefylline 40 mg/working day enhanced peak levels and AUC of CYP3A4 substrates in scientific trials. This outcome wasn't observed with istradefylline 20 mg/working day. Consider dose reduction of delicate CYP3A4 substrates.fentanyl transmucosal and diazepam both equally maximize sedation. Steer clear of or Use Alternate Drug. Limit use to patie